TGF-b2 in Aqueous Humor Suppresses S-Phase Entry in Cultured Corneal Endothelial Cells
نویسندگان
چکیده
PURPOSE. Corneal endothelium in vivo is arrested in G1, the phase of the cell cycle that prepares cells for DNA synthesis. In many cell types, transforming growth factor (TGF)-b inhibits proliferation by inducing G1-phase arrest. Evidence indicates that corneal endothelial cells synthesize mRNA for TGF-b1 and are also bathed in aqueous humor that contains TGF-b2 (mainly in a latent form). As such, this cytokine may maintain the corneal endothelium in a G1-phase–arrested state in vivo. The purpose of these studies was to determine the effect of exogenous TGF-b2 and TGF-b2 in aqueous humor on DNA synthesis in cultured corneal endothelial cells.
منابع مشابه
TGF-beta2 in aqueous humor suppresses S-phase entry in cultured corneal endothelial cells.
PURPOSE Corneal endothelium in vivo is arrested in G1, the phase of the cell cycle that prepares cells for DNA synthesis. In many cell types, transforming factor (TGF)-beta inhibits proliferation by inducing G1-phase arrest. Evidence indicates that corneal endothelial cells synthesize mRNA for TGF-beta1 and are also bathed in aqueous humor that contains TGF-beta2 (mainly in a latent form). As s...
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